pid lowering, anticancer activity, and inhibition of selected drug-metbolizing cytochrome P450 enzymes, including CYP3A4 and CYP1A2, which may result in drug-drug interactions in vivo. Ingestion of naringin and related flavonoids can also affect the intestinal absorption of certain drugs, leading to either an increase or decrease in circulating drug levels. To avoid interference with drug absorption and metbolism, the consumption of citrus (esp. grapefruit) and other juices with medications is c