date:Aug 10, 2012
e effects.
They found the optimal cancer-fighting dose for those taking sirolimus alone was about 90 mg per week. Though noted that the drug caused serious side effects including nausea and diarrhea at doses above 45 mg.
Participants taking sirolimus plus ketoconazole, needed only 16 mg per week to maintain the same levels of drug in the blood, whilst those taking sirolimus plus grapefruit juice required between 25 and 35 mg of sirolimus per week.
Although ketoconazole produced a slightly s